The Database of Sulfatases

Welcome to SulfAtlas, the database of sulfatases!

Widespread in nature, sulfated biomolecules are highly diverse in chemical structure and biological function. These compounds include sulfate esters (ROSO3-) and sulfamates (RN(H)SO3-) and range from small molecules to complex polymers. Sulfatases cleave sulfate groups from such molecules and constitute a biologically and industrially important group of enzymes. However, the number of sulfatases which have been characterized is limited in comparison to the huge diversity of the sulfated compounds. In the context of the explosion of genomic data, the functional annotation of sulfatases is thus particularly prone to flaws and misinterpretations. A classification system allowing for a better prediction of substrate specificity and for setting the limit of functional annotations was therefore urgently needed for sulfatases. SulfAtlas describes the family and sub-families of structurally-related sulfatases. Sub-families are created based on phylogenetic analyses and essentially correspond to different substrate specificities. Experimental evidences for the activity of new sulfatases will be regularly updated.

Version 2.3.1	July 2022	162,430 Entries (41,754: expert curated, 120,586: HMM classification; 151,467 available sulfatase sequences)
Version 1.3	March 2022	41,769 Entries (35,566 available sulfatase sequences)
Version 1.2	August 2021	41,541 Entries (35,857 available sulfatase sequences)
Version 1.1	February 2019	35,118 Entries (31,327 available sulfatase sequences)
Version 1.0	July 2013	4,550 Entries (4,543 available sulfatase sequences)